trans-golgi network meaning in English
高尔基体外侧网络
Examples
- Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome , while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network . the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status . the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins , including guanosine exchange factor ( gef ) , gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ) , and lays the foundations of rab function
Rab蛋白家族成员和其他小g蛋白一样可以结合gtp gdp ，在自身gtp酶的水解作用和其他蛋白( gef 、 gap 、 gdi )的调节作用下发生gtp (活化状态)和gdp (无活性)结合形式的转变；同时rab蛋白也在膜结合性( membrane - bound )和胞浆可溶性( cytosolic )之间变化，一个变化过程对应着一个功能循环，接着rab蛋白回到初始状态参与下一个循环。 - Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin , diphtheria toxin , shiga toxin and pseudomonas exotoxin ( pe ) . a number of these toxins are transported to trans - golgi network ( tgn ) , and in many cases such transport to the tgn is required for the translocation and cytotoxicity . in deed , 5 % of the ricin endocytosed by cells has been shown to reach the tgn
蓖麻毒素进入细胞的机理不甚明了，一般认为是rtb先与细胞膜受体结合，主要经过受体介导的内吞作用进入吞噬体，然后沿着内体、高尔基体、内质网等逆向分泌途径，有序地运输到内质网，最后从内质网转位进入细胞浆，在胞浆内攻击核糖体，从而抑制蛋白质的合成，导致细胞死亡。